Iodoethane → N-Ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide

Participants

Reaction Steps

To a solution of 4.0 g of sodium hydride (50% dispersion in oil) in 400 ml of anhydrous tetrahydrofuran was added 18.0 g of N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide. The solution was stirred (or 0.5 hrs, then 6.4 ml ethyl iodide was added. After stirring for 18 hours the reaction mixture was treated as described in Example 63 to give 19.8 g of colorless crystals, mp 116°-119° C. Recrystallization from acetone-hexane gave colorless crystals, mp 120°-121° C.

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