N-Methylhydrazinecarbothioamide → HCID 15595691, compound

HRID 329646Notes

Reaction equation

HRID 329646 reaction equation
[CH2:1]([N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]2[N:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=2)[CH:8]=1)[C:4](=[O:6])[CH3:5])[CH3:2].[CH3:20][NH:21][C:22](=S)[NH:23][NH2:24]>C(O)C>[CH2:1]([N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]3[N:15]([C:22]([NH:21][CH3:20])=[N:23][N:24]=3)[N:14]=2)[CH:8]=1)[C:4](=[O:6])[CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 2723853N-MethylhydrazinecarbothioamideHCID 14280297N-Ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide

Product 1

HCID 15595691HCID 15595691, compoundYield 26.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl) phenyl]acetamide and 5.3 g 4-methyl thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was worked up and the product chromatographed as described in Example 70. Recrystalization of the product fractions from dichloromethone-hexane afforded 2.1 g of yellow crystals, mp 193°-195° C.

Workup

  1. customthe product chromatographed
  2. customRecrystalization of the product fractions from dichloromethone-hexane

Sources & evidence

ORD record
ord-591026ff9b9248cb8ff4ff5833cdb09d
Source dataset
uspto-grants-1990_01
Patent number
US04892873

Reaction notes

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