Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Ethyl-3-thiosemicarbazide → N-Ethyl-N[3-[3-(ethylamino)-1,2,4-triazolo-[4,3-b]pyridazin-6-yl]phenyl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| 반응물 | N-Ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 14280297 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Ethyl-N[3-[3-(ethylamino)-1,2,4-triazolo-[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595692 | — |
반응 단계
A solution of 7.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl) phenyl]acetamide and 6.0 g 4-ethyl-3-thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then worked up and the product chromatographed as described in Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.1 g yellow flakes mp 171°-172° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04892873 |
| 출처 데이터셋 | uspto-grants-1990_01 |
| ORD ID | ord-a8551790e79848f9a833dc767c14831e |
| 출처 메모 | uspto-grants-1990_01 |