Hydrochloric Acid → HCID 67922906, compound

Participants

Reaction Steps

The solution of 3α,7β-diethoxycarbonyl-12α-hydroxy-23-methyl-5β-cholan-24-oic acid, methyl ester (0.6 g; 0.0011 mol) in 20 ml of a water/ethanol mixture (40/60) and 3 g of NaOH was refluxed for 12 hours, then treated with 80 ml of water, acidified with concentrated HCl and extracted with 4×40 ml of CHCl3. The organic solution was washed with NaCl-saturated water and dried on MgSO4. By chromatography on silica gel, under N2 -pressure (eluent: CHCl3), 340 mg of the title compound were obtained. M.p. 151°-153° C. The structure of the compound is fully confirmed by the analytical and spectral data.

Provenance & Evidence