HCID 70375074, compound → HCID 88616573, compound

HRID 329689Notes

Reaction equation

HRID 329689 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([CH3:22])[NH:15][C:14]([CH2:23][O:24][CH2:25][CH:26]2[CH2:30][O:29]C(C)(C)[O:27]2)=[C:13]1[C:33]([O:35][CH2:36][CH3:37])=[O:34]>C(O)(=O)C>[OH2:19].[Cl:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([CH3:22])[NH:15][C:14]([CH2:23][O:24][CH2:25][CH:26]([OH:27])[CH2:30][OH:29])=[C:13]1[C:33]([O:35][CH2:36][CH3:37])=[O:34].[Cl:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([CH3:22])[NH:15][C:14]([CH2:23][O:24][CH2:25][CH:26]([OH:27])[CH2:30][OH:29])=[C:13]1[C:33]([O:35][CH2:36][CH3:37])=[O:34]

Participants

3

Reactant 1

HCID 70375074HCID 70375074, compound

Product 1

HCID 88616573HCID 88616573, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-{[4-(2-Chloro-3-trifluoromethylphenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2,3-dihydroxypropane hemihydrate was prepared by the method described in the previous Example 4-{[4-(2-chloro-3-trifluoromethylphenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxymethyl}-2,2-dimethyl-1,3-dioxolane and 60% aqueous acetic acid. The product was characterised as a hemihydrate, m.p. 114° C.

Sources & evidence

ORD record
ord-c4a4e47a1a074a56ad9d80bc8941a707
Source dataset
uspto-grants-1990_01
Patent number
US04892881

Reaction notes

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