Dimethylformamide → HCID 14771558, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7.0 g of methyl 3-(2-bromo-2-methylpropionylamino)-5-chlorosalicylate, 3.6 g of potassium carbonate and 70 ml of dimethylformamide is stirred at 80° C. for 4 hours. After cooling, the resultant solution is poured into water and extracted with chloroform. The extract is washed with water and dried over magnesium sulfate followed by distillation of the solvent under reduced pressure to give 4.2 g of methyl 6-chloro-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazine-8-carboxylate, melting at 178°-179° C.

Provenance & Evidence