4-Methylmorpholine → HCID 19871151, compound

Participants

Reaction Steps

To a solution of 2.43 g of 3-aminoquinuclidine and 2.5 g of N-methylmorpholine in 50 ml of chloroform is added 5.2 g of 6-chloro-2-ethyl-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid chloride under cooling and stirring followed by stirring for 2 hours. The resultant solution is washed with water, aqueous sodium hydrogen carbonate and then water, and dried over magnesium sulfate. After the solvent is distilled off under reduced pressure, the residue is recrystallized from ethanolisopropyl ether and treated with ethanolic hydrochloric acid to give 6-chloro-2-ethyl-3,4-dihydro-4-methyl-3-oxo-N-(3-quinuclidinyl)-2H-1,4-benzoxazine-8-carboxamide hydrochloride, melting at 295° C. with decomposition.

Provenance & Evidence