反应详情

1-Benzoyloxy-2-methyl-3-tetrahydropyranyloxypropane (460 mg; 1.65 mmol) was dissolved in methanol (10 ml), and 1M sodium hydroxide solution (3 ml) and water (10 ml) were added thereto, and the resultant mixture was stirred at room temperature for 5 hours. The reaction mixture was extracted with ethyl acetate. The extracts were washed with water and dried over anhydrous magnesium sulfte. The solvent was removed by distillation, and the residue was purified by silica gel column chromatography using a mixture of ethyl acetate and benzene (1:4) to give 2-methyl-3-tetrahydropyranyloxy-1-propanol (254 mg; yield, 88%).

1. extractionThe reaction mixture was extracted with ethyl acetate
2. washThe extracts were washed with water
3. dry with materialdried over anhydrous magnesium sulfte
4. customThe solvent was removed by distillation
5. customthe residue was purified by silica gel column chromatography
6. additiona mixture of ethyl acetate and benzene (1:4)