Morpholine → 3-Morpholino-1-propanol

To a solution of 31.4 ml (360 mmol) of morpholine in 500 ml of diethyl ether were added slowly 10 g (71.94 mmole) of 3-bromopropanol and the mixture was stirred for one hour at room temperature. The reaction mixture was evaporated under vacuum and 300 ml of methylene chloride and 400 ml of a saturated aqueous solution of sodium bicarbonate were added. The mixture was shaken and he organic layer was separated and washed twice with 300-ml portions of saturated aqueous sodium bicarbonate. The organic layer was separated, dried over sodium sulfate and evaporated to yield 10.3 g of 3-morpholinopropanol.

1. customThe reaction mixture was evaporated under vacuum and 300 ml of methylene chloride and 400 ml of a saturated aqueous solution of sodium bicarbonate
2. additionwere added
3. stirringThe mixture was shaken
4. customhe organic layer was separated
5. washwashed twice with 300-ml portions of saturated aqueous sodium bicarbonate
6. customThe organic layer was separated
7. dry with materialdried over sodium sulfate
8. customevaporated

ORD record

ord-2ae1dbfb8efa43ada97499898db75d9d

Source dataset

uspto-grants-1990_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04892942