Sodium Carbonate → HCID 19871665, compound

HRID 329805Notes

Reaction equation

HRID 329805 reaction equation
[CH3:1][O:2][CH2:3][C:4](=[O:15])[CH:5]([CH:10]([CH3:14])[C:11]([CH3:13])=O)C(OC)=O.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:1][O:2][C:3]1[C:4](=[O:15])[CH2:5][CH:10]([CH3:14])[C:11]=1[CH3:13]

Participants

3

Reactant 2

HCID 10340Sodium CarbonateHCID 19871668Methyl 4-methoxy-2-(1-methylacetonyl)-acetoacetate

Product 1

HCID 19871665HCID 19871665, compound

Procedure

2.16 g (10 mmol) of methyl 4-methoxy-2-[1-methylacetonyl]-acetoacetate are held at reflux temperature for 2 hours with 21.2 ml (5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 1.40 g (100%) or 2-methoxy-3,4-dimethyl-2-cyclopenten-1-one, content 96%.

Workup

  1. extractionThe reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time
  2. dry with materialThe combined organic phases are dried over magnesium sulphate
  3. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-ad4afb7e1b7d4657a997aac876e0c9f6
Source dataset
uspto-grants-1990_01
Patent number
US04892966

Reaction notes

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