反应详情

2.16 g (10 mmol) of methyl 4-methoxy-2-[1-methylacetonyl]-acetoacetate are held at reflux temperature for 2 hours with 21.2 ml (5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 1.40 g (100%) or 2-methoxy-3,4-dimethyl-2-cyclopenten-1-one, content 96%.

1. extractionThe reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time
2. dry with materialThe combined organic phases are dried over magnesium sulphate
3. concentrationconcentrated on a rotary evaporator