反应详情

21.60 g(100 mmol) of methyl 4-methoxy-2-(2-oxobutyl)-acetoacetate are held at reflux temperature for 8 hours with 212.0 g (50 mmol) of 2.5% Na2CO3 solution. After cooling the reaction mixture is extracted 3 times with 200 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator. The crude product is column chromatographed over SiO2 and gives 4.08 g (29.1%) of 3-ethyl-2-methoxy-2-cyclopenten-1-one.

1. temperatureAfter cooling the reaction mixture
2. extractionis extracted 3 times with 200 ml of CH2Cl2 each time
3. dry with materialThe combined organic phases are dried over magnesium sulphate
4. concentrationconcentrated on a rotary evaporator
5. customchromatographed over SiO2