HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride monohydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride monohydrate | HCID 19871241 | 11.4% |
Reaction Steps
A mixture of o-nitrobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 and the product was further treated with methanolic hydrogen chloride to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride monohydrate as light yellow crystals, m.p. 162°-164° C. Yield 11.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-7dfd042f3e564ba7989f1b318ce86a4b |
| Source note | uspto-grants-1990_01 |