HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2-chlorophenyl)-2,6-dimethyl--1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2-chlorophenyl)-2,6-dimethyl--1,4-dihydropyridine-3,5-dicarboxylate | HCID 19871272 | — |
Reaction Steps
A mixture of o-chlorobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 4-(2-chlorophenyl)-2,6-dimethyl--1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 81°-83° C. (sintering). Yield (30.8%). IR(Nujol)cm-1 : 3320, 1680. NMR(CDCl3)δ: 2.26(6H,s, ##STR15## 3.56(3H,s,COOCH3), 4.12(2H,t,J=6,--COOCH2CH2 --), 4.17(1H,s, >N--CH<), 5.36(1H,s,C(4) --H), 5.63(1H,s,NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-24035eb2b51b4134ae6368a02d1881ef |
| Source note | uspto-grants-1990_01 |