HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → 2-(4-Benzhydryl-1-piperazinyl)ethyl ethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl ethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | HCID 19871237 | 34.7% |
Reaction Steps
A mixture of o-chlorobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 76°-78° C. (sintering). Yield 34.7%. IR(Nujol) cm-1 : 3320, 1690, 1680. NMR (CDCl3)δ:1.17(3H,t,J=7, --CH2CH3), 2.20(6H, s, ##STR16## 4.20(1H,s,>N--CH<), 5.40(1H,s,C(4) --H), 6.37(1H,s,NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-0917c1e8df7d4686a0bad0f5812f6f3d |
| Source note | uspto-grants-1990_01 |