HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichlorobenzaldehyde → 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichlorobenzaldehyde | HCID 35745 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | HCID 19871260 | 31.6% |
Reaction Steps
A mixture of 2,3-dichlorobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 84°-88° C. (sintering). Yield 31.6%. IR(Nujol)cm-1 : 3320, 1730, 1690. NMR(CDCl3) δ: 2.28(6H, s, ##STR17## 3.58(3H,s,COOCH3), 4.15(2H,t,J=6,--COOCH2CH2 --), 4.19(1H,s,>N--CH<), 5.45(1H,s,C(4) --H), 5.61(1H,s,NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-faebba8f99ae4dc5a65170070e382f43 |
| Source note | uspto-grants-1990_01 |