Isopropanol → HCID 19871231, compound

Participants

Reaction Steps

A mixture of m-nitrobenzaldehyde, 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 68°-72° C. (sintering). Yield 33.3%. This product was treated with methanolic hydrogen chloride to give colorless prisms of the dihydrochloride, m.p. 190°-193° C.

Provenance & Evidence