3-Nitrobenzaldehyde → HCID 19871196, compound

Participants

Reaction Steps

A mixture of m-nitrobenzaldehyde, 2-[4-(4,4'-dimethoxybenzhydryl)-1-piperazinyl]ethylacetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethoxybenzhydryl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 76°-80° C. (sintering). Yield 39.3%. IR(Nujol)cm-1 : 3330, 1695, 1680(shoulder). NMR(CDCl3) δ: 2.36(6H,s, ##STR21## 3.57(3H,s,--COOCH3), 3.75(6H,s,OCH3), 4.11(1H,s,>N--CH<), 4.15(2H,t,J=6, --COOCH2CH2 --), 5.08(1H,s,C(4) --H), 5.80(1H,broad s, NH).

Provenance & Evidence