Isopropanol → HCID 19871229, compound

Participants

Reaction Steps

A mixture of o-nitrobenzaldehyde, 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 90°-93° C. (sintering). Yield 21.3%. IR(KBr)cm-1 : 3350, 1695. NMR(CDCl3) δ: 2.26(3H,s, ##STR22## 2.31(3H,s, ##STR23## 3.53(3H,s,COOCH3), 4.0-4.3(3H,m,>N--CH<+--COOCH2CH2 --), 5.72(1H,s,C(4) --H), 5.77(1H,broad s, NH).

Provenance & Evidence