HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 19871216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethyl 3-oxobutanoate | HCID 15321205 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 19871216 | HCID 19871216 | 76.4% |
Reaction Steps
A mixture of m-nitrobenzaldehyde, 2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1, and the product obtained was further treated with a dioxane solution of hydrogen chloride to give 2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride as a light yellow powder, m.p. 108°-110° C. Yield 76.4%. NMR(DMSO-d6) δ: 2.30(3H,s, ##STR27## 2.38(3H,s, ##STR28## 3.60(3H,s,COOCH3), 4.48(2H,m,--COOCH2CH2 --), 5.03(1H,s,C(4) --H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-517c9c306a0e447da53b907030f40733 |
| Source note | uspto-grants-1990_01 |