3-Nitrobenzaldehyde → HCID 19871232, compound

Participants

Reaction Steps

A mixture of m-nitrobenzaldehyde, 2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give methyl 2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 95°-87° C. (sintering). Yield 82.7%. IR(Nujol)cm-1 : 3345, 1695, 1645. NMR(CDCl3) δ: 2.34(6H,s, ##STR31## 3.64(3H,s,COOCH3), 4.21(2H,t,J=5.5,--COOCH2CH2 --), 5.11(1H,s,C(4) --H), 6.39(1H,s,NH).

Provenance & Evidence