3-(Trifluoromethyl)benzaldehyde → HCID 19871258, compound

Participants

Reaction Steps

A mixture of m-trifluoromethylbenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 70°-72° C. Yield 52.5%. The product was further treated with methanolic hydrogen chloride and recrystallized from methanolethyl ether to give the dihydrochloride as colorless crystals, m.p. 168°-170° C.

Provenance & Evidence