2,3-Dichlorobenzaldehyde → HCID 19871227, compound

Participants

Reaction Steps

A mixture of 2,3-dichlorobenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 85°-88° C. (sintering). Yield 27.3%. IR(Nujol)cm-1 : 3330, 1690. NMR(CDCl3) δ: 1.14(3H,t,J=7,--CH2CH3), 2.25(12H,s, ##STR37## 4.05(2H,q,J=7,--CH2CH3), 4.08(1H,s,>N--CH<), 4.08(2H,t, J=6,--COOCH2CH2 --), 5.41(1H,s,C(4) --H), 5.68(1H,broad s, NH).

Provenance & Evidence