HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 19871265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Product | HCID 19871265 | HCID 19871265 | 46.3% |
Reaction Steps
A mixture of nicotinaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylate. Recrystallization from methanol gave colorless crystals, m.p. 227°-228° C. Yield 46.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-602a10a86f37451491e561e54e85d894 |
| Source note | uspto-grants-1990_01 |