Ammonia → HCID 67850894, compound

HRID 329866Notes

Reaction equation

HRID 329866 reaction equation
[C:1]([O:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH3:29]>C(O)C>[NH2:29]/[C:3](/[CH3:5])=[CH:2]\[C:1]([O:7][CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:14][CH2:15]1)=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11740518Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester

Product 1

HCID 67850894HCID 67850894, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate (3.21 g) in ethanol (5 ml), 20% ethanolic ammonia (15 ml) was added, and the mixture was allowed to stand in a refrigerator overnight. The solvent and ammonia were distilled off to give crude 2-(4-benzhydryl-1-piperazinyl)ethyl 3-aminocrotonate as an oil.

Workup

  1. customto stand in a refrigerator overnight
  2. distillationThe solvent and ammonia were distilled off

Sources & evidence

ORD record
ord-3d4a6820af864dd48024f2fdb5c670dc
Source dataset
uspto-grants-1990_01
Patent number
US04892875

Reaction notes

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