HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → HCID 19871222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 19871222 | HCID 19871222 | 32.8% |
Reaction Steps
A mixture of p-chlorobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a yellow powder, m.p. 75°-79° C. (sintering). Yield 32.8%. IR(Nujol)cm-1 : 3300, 1695, 1670. NMR(CDCl3) δ: 1.17(3H,t,J=7.5,--CH2CH3), 2.28(6H,s, ##STR38## 4.95(1H,s,C(4) --H), 5.77(1H,broad s, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-a0170dd579884ddbbc65923264a29d7f |
| Source note | uspto-grants-1990_01 |