Isopropanol → HCID 19871249, compound

Participants

Reaction Steps

A mixture of m-nitrobenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 82°-85° C. (sintering). Yield 50.8%. IR(Nujol)cm-1 : 3330, 1685. NMR(CDCl3) δ: 1.19(3H,t,J=7,--CH2CH3), 2.26(6H,s, ##STR40## 2.33(6H,s, ##STR41## 4.05(2H,q,J=7,--CH2CH3), 4.10(1H,s,>N--CH<), 4.12(2H,t,J=6,--COOCH2CH2 --), 5.07(1H,s,C(4) --H), 5.75(1H, broad s, NH).

Provenance & Evidence