Isopropanol → HCID 19871202, compound

Participants

Reaction Steps

A mixture of m-trifluoromethylbenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethyl 2,6-dimethyl-4-(3-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a colorless powder, m.p. 74°-77° C. (sintering). Yield 44.1%. IR(Nujol)cm-1 : 3320, 1680. NMR(CDCl3) δ: 1.17(3H,t,J=7,--CH2CH3), 2.26(6H,s, ##STR42## 2.32(6H,s, ##STR43## 4.05(2H,q,J=7,--CH2CH3), 4.10(1H,s,>N--CH<), 4.12(2H,t,J=6,--COOCH2CH2 --), 5.02(1H,s,C(4) --H), 5.65(1H, broad s, NH).

Provenance & Evidence