3-Chlorobenzaldehyde → HCID 19871209, compound

Participants

Reaction Steps

A mixture of m-chlorobenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethyl 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a colorless powder, m.p. 79°-81° C. (sintering). Yield 48.4%. IR(Nujol)cm-1 : 3330, 1680. NMR(CDCl3) δ: 1.16(3H,t,J=7,--CH2CH3), 2.22(6H,s, ##STR44## 2.28(6H,s, ##STR45## 4.05(2H,q,J=7,--CH2CH3), 4.08(1H,s,>N--CH<), 4.11(2H,t,J=6,--COOCH2CH2 --), 4.93(1H,s,C(4) --H), 5.64(1H, broad s, NH).

Provenance & Evidence