Methyl 3-formylbenzoate → HCID 70351527, compound

Participants

Reaction Steps

A mixture of m-methoxycarbonylbenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethy 4-(3-methoxycarbonylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 80°-83° C. (sintering). Yield 47.5%. IR(Nujol)cm-1 : 3330, 1720, 1690. NMR(CDCl3) δ: 1.17(3H,t,J=7,--CH2CH3), 2.25(6H,s, ##STR49## 2.31(6H,s, ##STR50## 3.83(3H,s,--COOCH3), 4.03(2H, q,J=7,--CH2CH3), 4.10(1H,s,>N--CH<), 4.10(2H,t,J=6, --COOCH2CH2 --), 5.00(1H,s,C(4) --H), 5.78(1H,broad s, NH).

Provenance & Evidence