4-Cyanobenzaldehyde → HCID 19871205, compound

Participants

Reaction Steps

A mixture of p-cyanobenzaldehyde, 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl acetoacetate and ethyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]ethyl ethyl 4-(4-cyanophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 93°-96° C. (sintering). Yield 61.9. IR(Nujol)cm-1 : 3330, 2220, 1685. NMR(CDCl3) δ: 1.15(3H,t,J=7,--CH2CH3), 2.24(6H,s, ##STR51## 2.29(6H,s, ##STR52## 4.03(2H,q,J=7,--CH2CH3), 4.11(1H,s,>N--CH<), 4.13(2H,t,J=7,--COOCH2 --), 5.01(1H, s,C(4) --H), 5.77(1H,broad s, NH).

Provenance & Evidence