HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 3-(4-Benzhydryl-1-piperazinyl)propyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 3-[4-(Diphenylmethyl)piperazin-1-yl]propyl 3-oxobutanoate | HCID 19871233 | — |
| Product | 3-(4-Benzhydryl-1-piperazinyl)propyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 20068676 | — |
Reaction Steps
A mixture of m-nitrobenzaldehyde, 3-(4-benzhydryl-1-piperazinyl)propyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 3-(4-benzhydryl-1-piperazinyl)propyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as an oil. This product was further treated with methanolic hydrogen chloride. Recrystallization from methanol gave the dihydrochloride as light yellow crystals, m.p. 168°-173° C. Yield 34.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-a85c85da651641e8871a3a3ef9fe92bb |
| Source note | uspto-grants-1990_01 |