3-Chlorobenzaldehyde → HCID 19871239, compound

Participants

Reaction Steps

A mixture of m-chlorobenzaldehyde, 2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 to give 2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl methyl 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 44°-49° C. (sintering). Yield 34.1%. IR(Nujol)cm-1 : 3430, 1700, 1685. NMR(CDCl3) δ: 2.30(3H,s, ##STR58## 2.34(3H,s, ##STR59## 3.63(3H,s,--COOCH3), 4.18(2H,t,J=6,--COOCH2CH2 --), 4.99(1H,s,C(4) --H), 5.69(1H,s,NH).

Provenance & Evidence