HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → 2-(4-Chlorobenzoyl)-2-(4-chlorophenyl)oxirane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,2-Ethanedione, 1,2-bis(4-chlorophenyl)- | HCID 18946 | — |
| Reactant | Urea, (nitrosomethyl)- | HCID 104823 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-Chlorobenzoyl)-2-(4-chlorophenyl)oxirane | HCID 19870084 | — |
Reaction Steps
With cooling and stirring, an ethereal diazomethane solution prepared by reaction of 5.34 g of N-nitrosomethylurea with aqueous sodium hydroxide solution in ether is added dropwise to a solution of 5 g of 4,4'-dichlorobenzil in 50 ml of dioxane. When the dropwise addition is complete, stirring is continued for 16 hours at room temperature, and the reaction solution is then concentrated by evaporation. The residual oil is crude 2-(4-chlorobenzoyl)-2-(4-chlorophenyl)oxirane which is purified by high vacuum distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04894083 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-057994b302f2495bbcf07f493a65ad1e |
| Source note | uspto-grants-1990_01 |