HCID 14773871, compound → HCID 13897640, compound

Participants

Reaction Steps

8-(Benzyloxy)-5-(hydroxymethyl)quinoline N-oxide (3) (0.5 g, 1.78 mmol) was added to a solution of pyridinium chlorochromate (0.42 g, 1.95 mmol) in methylene chloride (10 ml) and the solution was stirred for 1 h, then TLC indicated that the reaction was completed. The solution was then washed with water, dried over Na2SO4, and evaporated. The residue was passed through a short silica gel column using dichloromethane-methanol mixture (100:3) to elute the product. Evaporation gave a yellow solid (4) (0.27 g, 55%): mp 118°-121° C.; Rf 0.64 (chloroform-methanol, 9:1).

Provenance & Evidence