HuagongsheHuagongshe Chemistry Print Report · For research reference only
Uridine → 5-(3-Aminopropyl)-2'-deoxyuridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Uridine | HCID 6029 | — |
| Reactant | Acrylonitrile | HCID 7855 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(3-Aminopropyl)-2'-deoxyuridine | HCID 3081165 | — |
Reaction Steps
Uridine is reacted with mercuric chloride (5 mmol) at pH 5.0. 5-mercurichloride-dU so produced is reacted with acrylonitrile and lithium tetrachloro-palladiate in methanol yielding 5-(2-cyanoethyl) which is reduced by hydrogenation at 3 atmospheres in the presence of 10% palladium on charcoal in methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04894325 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-3261c37da1a445348fdc84c350518157 |
| Source note | uspto-grants-1990_01 |