Cyanamide → N-cyano-3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionamidine

HRID 329924Notes

Reaction equation

HRID 329924 reaction equation
CO[C:3](=[NH:18])[CH2:4][CH2:5][S:6][CH2:7][C:8]1[CH:13]=[C:12]([CH2:14][N:15]([CH3:17])[CH3:16])[CH:11]=[CH:10][N:9]=1.[N:19]#[C:20][NH2:21]>CO>[C:20]([NH:21][C:3](=[NH:18])[CH2:4][CH2:5][S:6][CH2:7][C:8]1[CH:13]=[C:12]([CH2:14][N:15]([CH3:17])[CH3:16])[CH:11]=[CH:10][N:9]=1)#[N:19]

Participants

4

Reactant 2

HCID 9864CyanamideHCID 19870407Methyl 3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionimidate

Product 1

HCID 178483279N-cyano-3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionamidine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl-3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionimidate is added to a methanol solution of cyanamide. After standing overnight N-cyano-3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionamidine is obtained.

Sources & evidence

ORD record
ord-652c688cd3b5409b90f515840566820c
Source dataset
uspto-grants-1990_01
Patent number
US04894372

Reaction notes

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