HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → HCID 177715839, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,5-Dihydro-3-chloro-6-diphenylmethoxy-2-methyl-5-oxo-1,2,4-triazine | HCID 19870401 | — |
| Reactant | (6R)-3-(aminomethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 88601874 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 177715839 | HCID 177715839 | — |
Reaction Steps
A solution of 3-aminomethyl-7-[2-(2-aminothiazol-4-yl)-2-((Z)-methoxyimino)acetamido]ceph-3-em-4-carboxylic acid (200 mg.), 2,5-dihydro-3-chloro-6-diphenylmethoxy-2-methyl-5-oxo-1,2,4-triazine (160 mg.) was triethylamine (200 ul.) in DMF (4 ml.) at 0° was allowed to stand for 3.5 hours. Formic acid (1 ml.) was added and the solvent was evaporated to give 7-[2-(2-aminothiazol-4-yl)-2-((Z)-methoxyimino)acetamido]-3-[(2,5-dihydro-6-diphenylmethoxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)aminomethyl]ceph-3-em-4-carboxylic acid which was used without further purification. nmr in solvent B:--3.52 (s, 3 H); 3.6 (s, 2 H); 4.04 (s, 3 H); 4.4 (s, 2 H); 5.18 (d, 1 H); 5.84 (d, 1 H); 7.1 (s, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04894371 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-92b3357d96f64a7ba5d8f0cc693ab717 |
| Source note | uspto-grants-1990_01 |