Acetic Acid → HCID 178460195, compound

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A mixture of 7-[2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido]-3-aminomethylceph-3-em-4-carboxylic acid (900 mg) and methyl 4-cyano-3-diphenylmethoxyisothiazol-5-sulphinate (800 mg) in solution in DMF (15 ml) containing 1 ml triethylamine was stirred at ambient temperature for five hours. The mixture was neutralised with HOAc and evaporated. The residue was purified by HPLC eluting with a 70/30 v/v mixture of methanol and water, and then with methanol to yield 700 mg of the desired product, nmr in solvent A 1.5 (s, 6 H); 3.8-4.1 (m, 2 H); 4.1-4.3 (m, 2 H); 5.15 (d, 1 H); 5.85 (d, 1 H); 7.0 (s, 1 H); 7.2-7.6 (m, 10 H).

Provenance & Evidence