HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]-pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Chlorothiophene-2-carbaldehyde | HCID 2735825 | — |
| Reactant | 2-Butenoic acid, 3-amino-, 1-methylethyl ester | HCID 11137274 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]-pyridine-3-carboxylate | HCID 13853275 | — |
Reaction Steps
40 mmol of 3-chloro-thiophene-2-carbaldehyde, 40 mmol of 3-acetoxyacetoacetic acid ester and 40 mmol of isopropyl 3-aminocrotonate are boiled under reflux over NaOH in EtOH, alcoholic hydrochloric acid is then added and the mixture is boiled for 1 hour. It is concentrated and the residue is crystallized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04894378 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-aee42490354240fa80b740a939dfb9d0 |
| Source note | uspto-grants-1990_01 |