Toluene → HCID 14537611, compound

Participants

Reaction Steps

A suspension of 47.4 g (0.133 mol) of methyl-triphenylphosphonium bromide and 15.3 g (0.137 mol) of potassium tert.-butylate in 250 ml of absolute toluene is heated under reflux for 30 minutes under dry nitrogen. 25.3 g (0.1 mol) of 1-(4-chlorophenyl)-4,4-dimethyl-3-heptanone, dissolved in 10 ml of absolute toluene, are then added dropwise during the course of 5 minutes. The reaction mixture is heated under reflux for a further 15 hours, then cooled to room temperature, washed twice with water and concentrated under reduced pressure. The residue is taken up in ethyl acetate, cooled to 5° C. and the crop of crystals formed is filtered off by suction. The filtrate is concentrated and distilled under reduced pressure. 23 g (91.8% of theory) of 2-(4-chlorophenylethyl)-3,3-dimethyl-1-hexene are obtained in the form of a yellow oil of boiling point 85°-87° C./0.1 mbar. ##STR30##

Provenance & Evidence