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HRID329960

反应详情

EQUATION

反应方程式

HRID 329960 的结构方程式

REACTANTS

反应物

2
结构：CCC(=O)Cl
HCID62324

Propanoyl chloride

C3H5ClO

结构：CCC(=O)O[C@H]1[C@@H]([N+]2(C)CCCCC2)C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOCC5)C[C@]4(C)[C@H]3CC[C@@]21C.[Br-]
HCID67897850

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H]([N+]3(C)CCCCC3)[C@@H]4OC(=O)CC)[C@@]2(C)C[C@@H]1N1CCOCC1.[Br-]
HCID67897746

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

Propanoyl chloride (5.24 ml) was added to a solution of 1-[(2β,3α,5α,16β,17β)-3-hydroxy-2(4-morpholinyl)-17-(1-oxopropoxy)-androstan-16-yl]-1-methylpiperidinium bromide (2.62 g) in dichloro-methane (33 ml) and the solution was set aside at room temperature for 20 h. The solution was evaporated to dryness under reduced pressure to give a gum, which was taken up in dichloromethane (15 ml) and purified by chromatography on alumina (Fluka type 5016A) (62 g) to give 1-[(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-3,17-bis(1-oxopropoxy)-androstan-16-yl]-1-methylpiperidinium bromide as a non-crystalline solid (1.99 g), [α]D20 =-16.7° (c 1.09 in CHCl3).

WORKUP

后处理

  1. customThe solution was evaporated to dryness under reduced pressure
  2. customto give a gum, which
  3. custompurified by chromatography on alumina (Fluka type 5016A) (62 g)