3-Fluorobenzyl chloride → HCID 13392778, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 0.3 g of 5-hydroxy-4-methoxymethyl-β-carboline-3-carboxylic acid ethyl ester is refluxed for 4 hours in 60 ml of ethanol with 0.3 g of potassium carbonate and 0.174 g of 3-fluorobenzyl chloride. After filtration and concentration under vacuum, the residue is chromatographed over silica gel (methylene chloride +ethanol/1000+25), thus obtaining 0.167 g of 5-(3-fluorobenzyloxy)-4-methoxymethyl-β-carboline-3-carboxylic acid ethyl ester, mp 188.0° C.

Provenance & Evidence