Sodium Hydroxide → HCID 67834666, compound

HRID 330017Notes

Reaction equation

HRID 330017 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([S:17][C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=1)[CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CO>[ClH:3].[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([S:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([OH:24])=[O:23])=[CH:26][CH:27]=1)[CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19870510HCID 19870510, compound

Product 1

HCID 67834666HCID 67834666, compoundYield 167.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

43 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 4.01 g of methyl 4-[1-(2-chlorophenyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 21) in 43 ml of methanol, and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was then treated and purified by the same method as described in Example 10, to give 3.57 g of the title compound as colorless crystals, melting at 210°-215° C.

Workup

  1. additionThe reaction mixture was then treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-7c5c263a83e04a79ad5d7ddbb1dc71e5
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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