Sodium Hydroxide → HCID 13913564, compound

Participants

Reaction Steps

1.6 ml of a 1N aqueous solution of sodium hydroxide was added to a solution of 170.6 mg of methyl 4-[1-(3,4,5-trimethoxyphenyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 27) in 1.6 ml of methanol, and the reaction mixture was stirred at room temperature for 2 hours. The solvent was then removed by distillation under reduced pressure, and 0.8 ml of a 1N aqueous solution of sodium hydroxide was added to the residue. The resulting mixture was extracted with chloroform, and the aqueous layer was adjusted to a pH value of 6.0 using concentrated hydrochloric acid and then extracted with chloroform. The chloroform extract was washed with a concentrated aqueous solution of sodium chloride and dried. The solvent was removed by distillation under reduced pressure, to give 91.4 mg of the title compound as a powdery substance, melting at 94°-97° C.

Provenance & Evidence