Hydrochloric Acid → HCID 13913566, compound

Participants

Reaction Steps

694 μl of a 1N aqueous solution of sodium hydroxide were added to a solution of 61.5 mg of methyl 4-[1-(2-hydroxyphenyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 33) in 694 μl of methanol, and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was then neutralized with 694 μl of a 1N aqueous solution of hydrochloric acid, and methanol was removed by distillation under reduced pressure. The remaining solution was subjected to chromatography through a Lobar column (Lichroprep, trade mark, RP-8, size B, produced by Merck) to give 32.2 mg of the title compound as a powdery substance, melting at 186°-190° C., from the fraction eluted with 30% v/v aqueous methanol.

Provenance & Evidence