Sodium Hydroxide → HCID 13913567, compound

HRID 330028Notes

Reaction equation

HRID 330028 reaction equation
[OH-].[Na+].[F:3][C:4]([F:30])([F:29])[C:5]1[CH:10]=[CH:9][C:8]([CH:11]([S:18][C:19]2[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=2)[CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:7][CH:6]=1>CO>[F:30][C:4]([F:3])([F:29])[C:5]1[CH:10]=[CH:9][C:8]([CH:11]([S:18][C:19]2[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)[CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19870505HCID 19870505, compound

Product 1

HCID 13913567HCID 13913567, compoundYield 62.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8 ml of a 1N aqueous solution of sodium hydroxide were added to 792 mg of methyl 4-[1-(4-trifluoromethylphenyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 35) in 8 ml of methanol, and the resulting mixture was stirred at room temperature for 4 hours. The reaction mixture was then treated and purified by the same method as described in Example 28, to give 481 mg of the title compound as a powder, melting at 92°-95° C.

Workup

  1. additionThe reaction mixture was then treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-3d3ec45e88994e7f9c650d3654d07cd1
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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