Sodium Hydroxide → HCID 19870534, compound

HRID 330035Notes

Reaction equation

HRID 330035 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([CH3:29])[CH:12]([N:24]1[CH:28]=[CH:27][N:26]=[CH:25]1)[S:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=1>CO>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([CH3:29])[CH:12]([N:24]1[CH:28]=[CH:27][N:26]=[CH:25]1)[S:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19870515HCID 19870515, compound

Product 1

HCID 19870534HCID 19870534, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.7 ml of a 1N aqueous solution of sodium hydroxide were added to 450 mg of methyl 4-[2-(2-methoxyphenyl)-1-(imidazol-1-yl)propylthio]benzoate prepared as described in Example 43) in 4.7 ml of methanol, and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was then treated and purified by the same method as described in Example 28, to give 300 mg of the title compound as a powder, melting at 118°-124° C.

Workup

  1. customprepared
  2. additionThe reaction mixture was then treated
  3. custompurified by the same method

Sources & evidence

ORD record
ord-ec8c62280d2d48c88e4bb86cfbabd68e
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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