Sodium Methoxide → HCID 14751595, compound

HRID 330041Notes

Reaction equation

HRID 330041 reaction equation
C(OC([O:11][C:12]1[C:21]2[C:16](=[C:17]([CH2:33][N:34]([C:41]([O:43][CH2:44][C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)=[O:42])[CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:18]([O:22]C(OCC3C=CC=CC=3)=O)=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[CH2:51][N:52]([C:59]([O:61][CH2:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=1)=[O:60])[CH:53]1[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]1)=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[OH:11][C:12]1[C:21]2[C:16](=[C:17]([CH2:33][N:34]([C:41]([O:43][CH2:44][C:45]3[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=3)=[O:42])[CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:18]([OH:22])=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[CH2:51][N:52]([C:59]([O:61][CH2:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=1)=[O:60])[CH:53]1[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 14751594HCID 14751594, compound

Product 1

HCID 14751595HCID 14751595, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the crude product from Step B (2.0 g, 2.3 mmol) in methanol (50 ml) was treated with sodium methoxide (120 mg, 2.2 mmol) for 18 hours at room temperature. The mixture was evaporated, the residue taken up in diethyl ether, acetic acid (1 ml) added, the solution washed three times with water, saturated acueous sodium chloride solution, dried (sodium sulfate) and evaporated. The crude product was vacuum filtered through a column of silica gel (Merck β 7734) eluted with 2:1 hexane-ether; yield 1.5 g.

Workup

  1. customThe mixture was evaporated
  2. additionacetic acid (1 ml) added
  3. washthe solution washed three times with water, saturated acueous sodium chloride solution
  4. dry with materialdried (sodium sulfate)
  5. customevaporated
  6. filtrationfiltered through a column of silica gel (Merck β 7734)
  7. washeluted with 2:1 hexane-ether

Sources & evidence

ORD record
ord-ca7973010ab64493a0ee1cc84c4f1996
Source dataset
uspto-grants-1990_01
Patent number
US04894392

Reaction notes

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