HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-Amino-20(RS)-camptothecin → 11-Amino-20(RS)-camptothecin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-Amino-20(RS)-camptothecin | HCID 355733 | — |
| Reactant | 2-Amino-4-nitrobenzaldehyde | HCID 13891180 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 11-Amino-20(RS)-camptothecin | HCID 355733 | — |
| Product | 2,4-Diaminobenzaldehyde | HCID 11147748 | — |
Reaction Steps
In a manner similar to that described for 10-nitro-20(RS)-camptothecin, a mixture of 2-amino-4-nitrobenzaldehyde is treated with the tricyclic ketone 11 yielding 11-nitro-20(RS)-camptothecin which in turn is reduced to 11-amino-20(RS)-camptothecin by palladium/carbon. Alternatively, the 11-amino-20(RS)-camptothecin is obtained by reaction of 2,4-diaminobenzaldehyde with ketone 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04894456 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-32d81ff655774e9980f8e5eac01371d3 |
| Source note | uspto-grants-1990_01 |