Sulfuric Acid → 2,4,5-Trifluoro-3-methylbenzoic acid

HRID 330078Notes

Reaction equation

HRID 330078 reaction equation
[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](N)=[O:5].S(=O)(=O)(O)[OH:15]>>[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([OH:15])=[O:5]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 140525692,4,5-Trifluoro-3-methylbenzamide

Product 1

HCID 118055142,4,5-Trifluoro-3-methylbenzoic acid

Procedure

A mixture of 2,4,5-trifluoro-3-methylbenzamide (0.38 g) in 18N sulfuric acid (3 ml) was stirred on an oil bath (100° to 110° C.) for 2 hours. After cooling, to the reacting mixture was added ice-water (10 ml), the resulting precipitate was collected by filtration and recrystallized from hexane to give the title compound (0.30 g) as colorless needles, mp 103°-105° C.

Workup

  1. temperatureAfter cooling, to the reacting mixture
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from hexane

Sources & evidence

ORD record
ord-0dd6b1790df548e48c011753de84ba03
Source dataset
uspto-grants-1990_01
Patent number
US04894458

Reaction notes

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